With 57-Down, protein building block WSJ Crossword Clue

By Narcissa Kh /

Crossword Answer

1 ? A
2 ? M
3 ? I
4 ? N
5 ? O
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      Hint 1

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      Think of what pieces together to form the structures that make us who we are.

      Hint 2

      meaning
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      ????? refers to a type of compound that forms the building blocks of proteins.

      Hint 3

      explanation
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      The clue refers to '?????' as part of the phrase '????? acid,' which is a fundamental component of proteins. The clue specifies 'With 57-Down,' indicating that the full answer requires another part from a different clue, likely 'acid.'

      Hint 4

      another clue
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      Important acid type, Question from someone seeking reassurance, Kind of protein-building acid, ___ acid (building block of proteins), Protein-building acid, informally

      Clue Analysis

      The clue “With 57-Down, protein building block” is a classic crossword staple, frequently appearing in puzzles like the WSJ crossword. For the puzzle dated March 2 2026, the definitive 5-letter answer is: AMINO.

      Expert Tip: When you’re stuck, try to analyze the structure of the clue itself. Is it a direct definition, a pun, a fill-in-the-blank, or a pop culture reference? Identifying the type of clue you’re dealing with is a key skill for improving your solving speed.

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      With 57-Down, protein building block Crossword Clue