___ mater (brain membrane) WSJ Crossword Clue

By Narcissa Kh /

Crossword Answer

1 ? P
2 ? I
3 ? A
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      Hint 1

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      Think of the tender guardian that hugs the brain closely.

      Hint 2

      meaning
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      ??? mater is the delicate innermost membrane enveloping the brain and spinal cord.

      Hint 3

      explanation
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      The clue refers to a specific layer of the meninges, which are the protective membranes surrounding the brain and spinal cord. '??? mater' is the innermost layer, known for being delicate and closely adhering to the brain's surface.

      Clue Analysis

      The clue “___ mater (brain membrane)” is a classic crossword staple, frequently appearing in puzzles like the WSJ crossword. For the puzzle dated November 4 2025, the definitive 3-letter answer is: PIA.

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      ___ mater (brain membrane) Crossword Clue