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High-level H.S. science class WSJ Crossword Clue

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Frequently Asked Questions About This Clue

The most common and recent 5-letter answer for "High-level H.S. science class" is APBIO.
The clue refers to a high school science class that is advanced or college-level, which is typically designated as 'AP' for Advanced Placement. 'BIO' is short for Biology, so 'APBIO' stands for Advanced Placement Biology.
This clue was last seen in the WSJ Crossword on May 02, 2026.
APBIO is an abbreviation for Advanced Placement Biology, a college-level biology course offered in high school.
2018-21 sitcom set at Whitlock High, H.S. class for tough life lessons?, Pre-med track precursor, in brief, Difficult H.S. course

The clue “High-level H.S. science class” is a classic crossword staple, frequently appearing in puzzles like the WSJ crossword. For the puzzle dated May 2 2026, the definitive 5-letter answer is: APBIO.

Expert Tip: When you’re stuck, try to analyze the structure of the clue itself. Is it a direct definition, a pun, a fill-in-the-blank, or a pop culture reference? Identifying the type of clue you’re dealing with is a key skill for improving your solving speed.

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