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Lou Gehrig’s disease, for short WSJ Crossword Clue

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Frequently Asked Questions About This Clue

Lou Gehrig’s disease, for short
The most common and recent 3-letter answer for "Lou Gehrig’s disease, for short" is ALS.
The clue refers to Amyotrophic Lateral Sclerosis, a disease famously associated with baseball player Lou Gehrig. 'For short' indicates that the answer is an abbreviation of the disease's name, which is 'ALS.'
This clue was last seen in the WSJ Crossword on October 31, 2026.
ALS is an abbreviation for Amyotrophic Lateral Sclerosis, a progressive neurodegenerative disease.
Green, Gore and more, Lou Gehrig's disease, in brief, Hirt and Hirschfeld, Singers Green and Jardine, Gore and more

The clue “Lou Gehrig’s disease, for short” is a classic crossword staple, frequently appearing in puzzles like the WSJ crossword. For the puzzle dated October 31 2026, the definitive 3-letter answer is: ALS.

Expert Tip: When you’re stuck, try to analyze the structure of the clue itself. Is it a direct definition, a pun, a fill-in-the-blank, or a pop culture reference? Identifying the type of clue you’re dealing with is a key skill for improving your solving speed.

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