Prefix with American NYT Crossword Clue

By Emre Parlak / May 22, 2026

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Crossword Answer

1 ? M

2 ? E

3 ? S

4 ? O

Hint

Interactive Solver for Prefix with American Crossword Clue

Drag letters from the pool into “Your Answer”, then reorder them to match the solution.

Your Answer 4 Letter

Current guess: —

Letter Pool

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Hint 1

hint

Reveal Hint

Think of ancient civilizations that thrived before the modern era in a region south of the USA.

Hint 2

meaning

Reveal Hint

????- is a prefix meaning middle, intermediate, or in between.

Hint 3

explanation

Reveal Hint

The clue 'Prefix with American' refers to a prefix that can be combined with the word 'American' to form a recognized term. 'Mesoamerican' relates to the cultures and regions in Central America before the Spanish conquest, such as the Maya and Aztec civilizations.

NYT Crossword May 22 2026 Answers

Tap a cell to show its letter

1 ? B
2 ? I
3 ? C
4 ? E
5 ? P
6 ? S
7 ? M
8 ? E
9 ? S
10 ? O
11 ? B
12 ? R
13 ? I
14 ? E
15 ? E
? T
? A
? L
? I
? I
16 ? O
? A
? K
? F
17 ? O
? R
? E
? S
? T
18 ? A
? S
? K
? I
? N
? G
19 ? F
? O
? R
? A
? F
? R
? I
? E
? N
? D
20 ? K
? N
? E
? E
21 ? M
? O
? N
? T
22 ? D
? O
? L
? T
? S
23 ? S
? O
? S
24 ? C
? A
? L
? L
? H
25 ? O
26 ? M
? E
27 ? T
? I
28 ? S
? H
29 ? K
? I
? L
? M
? E
? R
30 ? O
31 ? L
32 ? A
33 ? O
? H
? C
? O
? O
34 ? L
35 ? G
? I
? N
? A
36 ? K
? P
? O
? P
37 ? K
? I
? L
? L
? W
? I
38 ? T
? H
? K
? I
? N
39 ? D
? N
? E
? S
? S
40 ? O
? N
? E
? D
41 ? N
? O
? T
? E
42 ? S
? E
? E
? N
? T
? O
43 ? K
? G
? S
44 ? P
? E
? T
? S
? P
45 ? A
46 ? A
? W
? O
? L
47 ? U
? N
? S
? O
? L
? V
48 ? E
? D
49 ? F
? U
50 ? L
51 ? O
52 ? C
53 ? C
54 ? A
? M
55 ? N
? A
? I
? R
56 ? I
? F
? S
? O
57 ? A
? L
? L
? B
? A
58 ? R
59 ? K
? A
? N
? D
? N
60 ? O
? B
? I
? T
? E
61 ? F
? O
? O
? L
? S
? M
? A
? T
? E
62 ? S
? P
? I
? C
? E
? S
63 ? S
? T
? Y
? E
64 ? S
? L
? A
? T
65 ? T
? A
? S
? E
? R
? S

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31D

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48D

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50D

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51D

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53D

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54D

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56D

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59D

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Clue Analysis

The 4-letter answer to “Prefix with American” in the NYT Crossword May 22 2026 is MESO.

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Your Questions, Answered by Experts.

At Daze Puzzle, we understand that every clue is a puzzle within a larger puzzle. Our team of dedicated human experts and puzzle lovers solves these challenges daily to help you succeed. Below, we answer common questions about this specific clue.

A: The most common and recent 4-letter answer for "Prefix with American" is MESO.

A: The clue 'Prefix with American' refers to a prefix that can be combined with the word 'American' to form a recognized term. 'Mesoamerican' relates to the cultures and regions in Central America before the Spanish conquest, such as the Maya and Aztec civilizations.

A: This clue was last seen in the NYT Crossword on May 22, 2026.

A: Meso- is a prefix meaning middle, intermediate, or in between.

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Prefix with American NYT Crossword Clue

Crossword Answer

Interactive Solver for Prefix with American Crossword Clue